Fn 1 autImit 4 unniwinfhlvmm 000 ni / ISCIFI Toxicity and residues of oxolinic acid

نویسنده

  • Somchai Issaravanich
چکیده

Peerasak Chantaraprateep, Palarp Sinhaseni, Venus Udomprasertgul, Benjaphorn Rungphitackchai, Somchai Issaravanich and Rerngsak Boonbundarichai. 1998. Toxicity and residues of oxolinic acid. Thai J Hlth Resch 12(2): 125 139. Oxolinic acid is a quinolone derivative. It is a synthetic antimicrobial agent which used to treat bacterial urinary tract infections, especially gram negative bacteria. It has been used in veterinary medicine for the control of furunculosis, vibriosis and enteric redmouth diseases. The mechanism of action of oxolinic acid inhibited bacterial DNA synthesis by effecting on bacterial DNA gyrase. Toxicity of oxolinic acid occured mainly to the central nervous system and gastrointestinal tract. Most of studies of residues of oxolinic acid were found in aquaculture animals such as fish and shrimp because oxolinic acid is used worldwide in aquaculture industry. The studies found that the absorption of oxolinic acid in rainbow trout depended on the temperature of water. And the residue time of oxytetracycline in sediment was longer than oxolinic acid. In addition, oxolinic acid in hepatopancreas of shrimp had more higher concentration than haemolymph and muscle and it also persisted in hepatopancreas longer than muscle.

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تاریخ انتشار 2009